Muthusamy Jayaraman Selected Research

6- (3- (2- hydroxyethyl)amino- 1- propyl)- 5,6- dihydro- 2,3- dimethoxy- 8,9- methylenedioxy- 5,11- dioxo- 11H- indeno(1,2- )isoquinoline

2/2005	Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison.
11/2003	Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

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Muthusamy Jayaraman Research Topics

Disease

4	Neoplasms (Cancer) 06/2012 - 01/2002
2	Hypercholesterolemia 01/2022 - 08/2008
1	Primary Hyperoxaluria (Oxaluria, Primary) 01/2022
1	Rheumatoid Arthritis 01/2012
1	Inflammation (Inflammations) 01/2012
1	Disease Progression 01/2012
1	Poisoning 02/2005
1	Vaccinia 11/2003

Drug/Important Bio-Agent (IBA)

2	LigandsIBA 01/2022 - 06/2012
2	6- (3- (2- hydroxyethyl)amino- 1- propyl)- 5,6- dihydro- 2,3- dimethoxy- 8,9- methylenedioxy- 5,11- dioxo- 11H- indeno(1,2- )isoquinolineIBA 02/2005 - 11/2003
1	AcetylgalactosamineIBA 01/2022
1	givosiranIBA 01/2022
1	OligonucleotidesIBA 01/2022
1	Acute Hepatic PorphyriaIBA 01/2022
1	ALN-PCSIBA 01/2022
1	Antisense OligonucleotidesIBA 01/2022
1	lumasiranIBA 01/2022
1	Peptides (Polypeptides)IBA 06/2012
1	Folic Acid (Vitamin M)FDA LinkGeneric 06/2012
1	DNA (Deoxyribonucleic Acid)IBA 06/2012
1	Small Interfering RNA (siRNA)IBA 01/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012
1	Proteins (Proteins, Gene)FDA Link 02/2005
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 11/2003
1	LactonesIBA 11/2003
1	SaltsIBA 01/2002
1	Type I DNA Topoisomerases (Topoisomerase I)IBA 01/2002

Therapy/Procedure

2	Therapeutics 01/2022 - 01/2012
1	RNAi Therapeutics 08/2008